ea0029p1354 | Pituitary Basic | ICEECE2012
Garcia-Rendueles
, Diaz-Rodriguez E.
, Trivellin G.
, Garcia-Lavandeira M.
, Vila Vila T.
, Dieguez C.
, Korbonitz M.
, Alvarez C.
Introduction: About 30% of all familial isolated pituitary adenoma (FIPA) and 50% of acromegaly families have a mutation in the aryl hydrocarbon receptor-interacting protein gene (AIP; Chahal, TEM, 2010). The functional role of AIP in somatotroph cells is unknown. Recently, it has been proposed that wild type AIP (wtAIP) is a tumor suppressor gene, role that is lost in the different mutant AIPs (mAIP; Leontiou, JCEM, 2008). In the adenomas, mAIPs are usually foun...